解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Dihydrogoniothalamin is a styrylpyrone isolated from the leaves of Aniba panurensis. The present work aimed at investigating the vasorelaxant activity of dihydrogoniothalamin and its underlying mechanism of action in the rat aorta. Dihydrogoniothalamin (0.01-100 µM) induced a concentration-dependent vasodilatation of ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1557775
更新日期:2015-10-01 00:00:00
abstract::Olive mill waste water is the major byproduct of the olive oil industry containing a range of compounds related to Olea europaea and olive oil constituents. Olive mill waste water comprises an important environmental problem in olive oil producing countries, but it is also a valuable material for the isolation of high...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1546243
更新日期:2015-08-01 00:00:00
abstract::Propolis is a cereus resin with a complex chemical composition that possesses a wide range of biological activities. The aim of this study was to evaluate the in vitro anti-Giardia lamblia activity of Sonoran propolis collected from three different areas of Sonoran Desert in northwestern Mexico (Caborca, Pueblo de Ala...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1545982
更新日期:2015-06-01 00:00:00
abstract::Ischemic preconditioning, which is mediated by cell signaling molecules, protects the heart from ischemia-reperfusion injury by limiting the infarct size. Oleuropein, the main polyphenolic constituent of olives, reduced the infarct size in normal and cholesterol-fed rabbits when it was administered at a nutritional do...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0034-1383306
更新日期:2015-06-01 00:00:00
abstract::Praziquantel is the drug of choice for the treatment of schistosomiasis. However, several strains of Schistosoma mansoni are resistant to praziquantel, making it necessary to discover new drugs that might be used for its treatment. With this in mind, the properties of a schistosomicidal ethanolic extract of Garcinia b...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1545927
更新日期:2015-06-01 00:00:00
abstract::The olive (Olea europaea) leaf is considered an important traditional herbal medicine utilized against infectious diseases, and for the treatment of diabetes and hypertension. Moreover, olive leaf constituents have been related to cardioprotection, probably due to their association with cellular redox modulating effec...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0035-1546017
更新日期:2015-06-01 00:00:00
abstract::Cissampentine A (1), an enantiomer of cissampentin, three new cycleatjehenine-type bisbenzylisoquinoline alkaloids, cissampentine B-D (2-4), and five known alkaloids were isolated from the roots of Cyclea tonkinensis. Their structures were established by interpretation of NMR, high-resolution ESI-MS data, and CD spect...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1545882
更新日期:2015-05-01 00:00:00
abstract::We present the application of the generative topographic map algorithm to visualize the chemical space populated by natural products and synthetic drugs. Generative topographic maps may be used for nonlinear dimensionality reduction and probabilistic modeling. For compound mapping, we represented the molecules by two-...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0034-1396322
更新日期:2015-04-01 00:00:00
abstract::This in vitro study aimed to determine the effects of a Panax ginseng extract on aristolochic acid-mediated toxicity in HK-2 cells. A methanolic extract of ginseng (50 µg/mL) was able to reduce cell survival after treatment with 50 µM aristolochic acid for 24, 48, and 72 h, as evidenced by a resazurin reduction assay....
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1545839
更新日期:2015-03-01 00:00:00
abstract::Myrrh is the oleo-gum resin of mainly Commiphora molmol and as a powdered substance, one compound in the traditional medicinal product Myrrhinil-Intest®, which has been used for the treatment of unspecific, inflammatory intestinal disorders. The aim of the present study was to evaluate the antispasmodic effect of myrr...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0034-1383391
更新日期:2015-01-01 00:00:00
abstract::The fruit of Ziziphus jujuba Mill., known as jujube or Chinese date, is commonly consumed as health supplement or herbal medicine worldwide. To study the beneficial role of jujube in enhancing hematopoietic function, we investigated its roles on the expression of erythropoietin in cultured Hep3B human hepatocellular c...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0034-1383049
更新日期:2014-11-01 00:00:00
abstract::The leaves of Myrcia ovata, popularly known as "laranjinha do mato", are frequently used as an infusion in folk medicine. The essential oil obtained from these leaves is rich in citral, a mixture of neral and geranial isomers, known for its analgesic effect. Male Swiss mice (20-22 g) were tested in models of acute pai...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0034-1383120
更新日期:2014-11-01 00:00:00
abstract::For quantitative determination of grayanotoxin I (1) in plant material, a GC/MS method was developed after trimethylsilyl derivatisation of the analytes. Forskolin (5) was used as an internal standard for quantification. ICH-compliant method validation indicated sufficient specificity, precision, quantitation (15 µg/m...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0034-1383039
更新日期:2014-10-01 00:00:00
abstract::Seven new clerodane diterpenoids, dysoxydensins A-G (1-7), together with six known clerodanes, were isolated from Dysoxylum densiflorum. The structures of all the compounds were elucidated by extensive spectroscopic analysis. These compounds were evaluated for their cytotoxic activities against five human cancer cell ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0034-1382903
更新日期:2014-08-01 00:00:00
abstract::Rhapontin was purified from a methanol extract from the roots of Rheum undulatum, and rhapontigenin was produced by an enzymatic transformation of rhapontin. Rats were fed a high-cholesterol diet to induce hyperlipidemia, followed by oral treatment with rhapontin or rhapontigenin (1-5 mg/kg/day). Rhapontin and rhapont...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0034-1382999
更新日期:2014-08-01 00:00:00
abstract::Three new vermistatin derivatives, 6-demethylpenisimplicissin (1), 5'-hydroxypenisimplicissin (2), and 2''-epihydroxydihydrovermistatin (3), along with five known vermistatin analogues, methoxyvermistatin (4), vermistatin (5), 6-demethylvermistatin (6), hydroxyvermistatin (7), and penisimplicissin (8), were isolated f...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0034-1382859
更新日期:2014-07-01 00:00:00
abstract::In obese adipose tissue, tumor necrosis factor-α secreted from macrophages plays an important role in the adipocyte dysfunctions, including insulin resistance, lipolytic acceleration, and changes of adipokines, which promote the development of obesity-related complications. Phillyrin, an active ingredient found in man...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0034-1368614
更新日期:2014-07-01 00:00:00
abstract::A method was developed to distinguish Vaccinium species based on leaf extracts using nuclear magnetic resonance spectroscopy. Reference spectra were measured on leaf extracts from several species, including lowbush blueberry (Vaccinium angustifolium), oval leaf huckleberry (Vaccinium ovalifolium), and cranberry (Vacci...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0034-1368569
更新日期:2014-06-01 00:00:00
abstract::Based on the fact that Synadenium grantii is used in folk medicine for the treatment of peptic ulcers and inflammatory diseases, this work describes its chemical and pharmacological properties. Pharmacological investigation of the crude bark extract showed a high antioxidant activity over several scavenger systems, su...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0034-1368300
更新日期:2014-04-01 00:00:00
abstract::In our previous study, we reported the interesting in vitro antiplasmodial activity of some Rwandan plant extracts. This gave rise to the need for these extracts to also be evaluated in vivo and to identify the compounds responsible for their antiplasmodial activity. The aim of our study was, on the one hand, to evalu...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0034-1368322
更新日期:2014-04-01 00:00:00
abstract::Diabetes mellitus is one of the major health problems in Africa. The conventional oral synthetic antidiabetic drugs available to manage the disease are costly and not readily affordable to the majority of the affected population. Interestingly, the continent is endowed with a tremendous number of medicinal plants that...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0033-1360335
更新日期:2014-03-01 00:00:00
abstract::Six dietary isothiocyanates, allyl-isothiocyanate, benzyl-isothiocyanate, phenylethyl-isothiocyanate, sulforaphane, erucin, and iberin, were tested for their trypanocidal activities in vitro using culture-adapted bloodstream forms of Trypanosoma brucei. All isothiocyanates showed a dose-dependent effect on the growth ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0033-1360262
更新日期:2014-02-01 00:00:00
abstract::Danggui buxue tang, an ancient formula composed of astragali radix and Angelicae sinensis radix, has been used for treating menopausal irregularity in women for more than 800 years in China. In danggui buxue tang, the complete functions of astragali radix require the assistance of Angelicae sinensis radix, and both he...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0033-1360314
更新日期:2014-02-01 00:00:00
abstract::O-Methyl (1), O-ethyl (2), and O-butyl (3) 4-[(α-L-rhamnosyloxy) benzyl] thiocarbamate (E), along with 4-(α-L-rhamnosyloxy) benzyl isothiocyanate (4) have been isolated from the aerial parts of Moringa peregrina. The compounds were tested for in vitro activity against Trypanosoma brucei rhodesiense and cytotoxicity in...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0033-1351102
更新日期:2014-01-01 00:00:00
abstract::Tuberculosis, also called TB, is currently a major health hazard due to multidrug-resistant forms of bacilli. Global efforts are underway to eradicate TB using new drugs with new modes of action, higher activity, and fewer side effects in combination with vaccines. For this reason, unexplored new sources and previousl...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0033-1350978
更新日期:2014-01-01 00:00:00
abstract::The aggregation of the microtubule-associated protein tau is a significant event in many neurodegenerative diseases including Alzheimer's disease. The inhibition or reversal of tau aggregation is therefore a potential therapeutic strategy for these diseases. Fungal natural products have proven to be a rich source of u...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0033-1360180
更新日期:2014-01-01 00:00:00
abstract::This paper reports the phytochemical investigation of the 50% aq. EtOH extract of Houttuynia cordata, an effective TCM and functional food in China, which led to the isolation of 17 flavonoids including four new ones. The four new compounds were flavonoid derivatives tethered with houttuynin (3-oxododecanal). Each of ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0033-1351051
更新日期:2013-12-01 00:00:00
abstract::Three new sauchinone analogues, sauchinones B-D (1-3), together with sauchinone (4), were isolated from the aerial part of Saururus chinensis. Structures of the new compounds were determined by extensive spectroscopic data as well as X-ray analysis. Compounds 3 and 4 inhibited nitric oxide production in lipopolysaccha...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0033-1351053
更新日期:2013-12-01 00:00:00
abstract::Bryophyllum pinnatum is a succulent perennial plant native to Madagascar which is used in anthroposophical medicine to treat psychiatric disorders and as a tocolytic agent to prevent premature labour. We performed a metabolite profiling study in order to obtain a comprehensive picture of the constituents in B. pinnatu...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0033-1350808
更新日期:2013-11-01 00:00:00
abstract::Qianhu, the dried roots of Peucedanum praeruptorum, is a well-known traditional Chinese medicinal herb which was officially listed in the Chinese Pharmacopoeia. Praeruptorin A is the major active constituent of Qianhu. Our previous studies show that praeruptorin effectively transactivated the protein expression and ca...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0033-1350795
更新日期:2013-11-01 00:00:00
abstract::3,6'-Disinapoylsucrose is a major active component of the herb Polygala tenuifolia which has long been used for relieving tranquilization, uneasiness of the mind, and improving learning and memory. Our previous study found that 3,6'-disinapoylsucrose had a very low oral bioavailability. Its mechanisms of absorption in...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0033-1350794
更新日期:2013-10-01 00:00:00
abstract::Ligusticum canbyi (J.M. Coult & Rose) is a medicinal understory forest species used in traditional rituals and ceremonies for spiritual enlightenment and improved mental health. Very little is known about the phytochemical complexity or diversity of L. canbyi tissues or extracts. The current study was undertaken to de...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0033-1350618
更新日期:2013-09-01 00:00:00
abstract::It has been known that silymarin exhibits protective activity against oxidative liver injury induced by various hepatotoxicants, but the underlying mechanism of its beneficial action remains unclear. We determined the alterations in sulfur-containing amino acid metabolism induced by silymarin in association with its e...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1328704
更新日期:2013-08-01 00:00:00
abstract::Five new dibenzocyclooctane lignans, schisanwilsonins K-O, together with eighteen known lignans were isolated from the stems of Schisandra wilsoniana. The structures of these new compounds were elucidated by spectroscopic methods, including 2D-NMR techniques. Several compounds were found to show anti-HIV and anti-HBV ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1328747
更新日期:2013-08-01 00:00:00
abstract::Leaves of Ligustrum vulgare (common privet) have been used for treatment of oropharyngeal inflammations or as antirheumatic, diuretic, and hypotensive agents in folk medicine in southern Europe. Taking into account that neutrophils are involved in the inflammation, the aim of the study was to determine the effect of a...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1328718
更新日期:2013-07-01 00:00:00
abstract::Six new triterpenoid saponins, psychotrianosides A-F (1-6), and two known triterpenoid saponins, psychotrianoside G (7) and ardisianoside D (8), were isolated from Psychotria sp. Their structures were determined mainly by spectroscopic methods. The cytotoxic activities of 1-8 against five human cancer cell lines (MDA-...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1328650
更新日期:2013-07-01 00:00:00
abstract::Matrine and arsenic trioxide are monomers used in traditional Chinese medicine possessing anti-myeloma activities. In this study, we evaluated the effects and mechanisms of matrine, arsenic trioxide, and their combination therapy on the proliferation and apoptosis of the myeloma cell lines RPMI8226 and U266. The effec...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1328554
更新日期:2013-06-01 00:00:00
abstract::Three new xanthones, 22,23-dihydroxydihydrogambogenic acid (1), 12-hydroxygambogefic acid A (2), and hanburixanthone (3), along with thirteen known compounds were isolated from the resin of Garcinia hanburyi. The structures of the new compounds were determined by detailed analysis of 1D and 2D NMR spectra and by compa...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1328537
更新日期:2013-06-01 00:00:00
abstract::Five new compounds, including one new xanthone, 1-hydroxy-5-methoxyxanthone 6-O-β-D-glucopyranoside (1), one new lignan, 3-(β-D-glucopyranosyloxymethyl)-2-(4-hydroxy-3-methoxyphenyl)-5-(3-acetoxypropyl)-7-methoxy-(2R,3S)-dihydrobenzofuran (2), and three new γ-pyrones, japonicumone A 4'-O-β-D-glucopyranoside (3), japon...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1328538
更新日期:2013-05-01 00:00:00
abstract::Phytochemical investigation of the dichloromethane extract of the leaves of Peltophorum pterocarpum, a tropical ornamental tree, led to the isolation of twelve compounds (1-12). One new derivative of peltogynoid ophioglonin (1) and a new 2-phenoxychromone (2) with its 3'-O-β-D-glucoside derivative (3) are described he...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1328299
更新日期:2013-04-01 00:00:00